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Seattle-Denver Center of Innovation (COIN)


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COIN Investigators & Staff

COIN Investigators


Liron Caplan, MD, PhD
Title: Section Head, Rheumatology
University of Colorado Division of Rheumatology
Location: Denver
University of Colorado webpage
See Dr. Caplan's Dimensions profile that includes: publications, grants, datasets, patents and clinical trials
Dr. Caplan engages in clinically-oriented epidemiologic and health service research within the field of pharmacoepidemiology and auto-immunity/rheumatology. Areas of interest include spondyloarthritis, retrospective analysis of databases, as well as construction and maintenance of patient registries.
I have chosen to pursue research in spondyloarthritis because this population is scientifically fascinating, understudied, and faces clinically important health challenges. I find the veterans to be extremely generous with their time and motivated to solve questions related to their health, and that is extremely rewarding.
I hope that we are able to bring meaningful change to individuals with spondyloarthritis, with more certain diagnoses made earlier in patient’s disease course.

The following images visualize Dr. Caplan's work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):

Dr. Caplan's publication titles indicate his primary work is care of Veterans
Word cloud from pub titles
Dr. Caplan's collaborations are primarily from the University of Colorado
Research collaboration map
The following research fields have been used to summarize Dr. Caplan's publications and grants. The categories are based on 127 publications and 1 grant.
Publications Grants
Clinical Research Cardiovascular
Arthritis Health Services
Autoimmune Disease Heart Disease - Coronary Heart Disease
Prevention Heart Disease
Cardiovascular Behavioral and Social Science
Rheumatoid Arthritis Clinical Research
Aging Clinical Trials and Supportive Activities
Heart Disease Patient Safety
Diabetes Prevention
Heart Disease - Coronary Heart Disease  

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Recent Publications



Stoll ML, Huizar E, Caplan L. Back to the Future: Is the Schober Test Dispensable in Juvenile Spondyloarthritis? J Rheumatol. 2023 Feb 1:jrheum.221231. doi: 10.3899/jrheum.221231. Epub ahead of print. PMID: 36725058
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Sen R, Caplan L. Current treatment and molecular targets for axial spondyloarthritis: Evidence from randomized controlled trials. Curr Opin Pharmacol. 2022 Nov 3;67:102307. doi: 10.1016/j.coph.2022.102307. Epub ahead of print. PMID: 36335714
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Sen R, Kim E, Napier RJ, Cheng E, Fernandez A, Manning ES, Anderson ER, Maier KD, Hashim M, Kerr GS, Fang MA, Hou JK, Chang E, Walsh JA, Raychadhuri SP, Reimold A, Caplan L. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as biomarkers in axial spondyloarthritis: observational studies from the PULSAR registry. Arthritis Rheumatol. 2022 Aug 26. doi: 10.1002/art.42333. Epub ahead of print. PMID: 36053919
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Caplan AM, Caplan L. The GRADE Method. Rheum Dis Clin North Am. 2022 Aug;48(3):589-599. doi: 10.1016/j.rdc.2022.04.002. Epub 2022 Jul 5. PMID: 35953225
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Maksymowych WP, Lambert RGW, Caplan L, van den Bosch FE, Østergaard M. Improving the design of RCTs in non-radiographic axial spondyloarthritis. Nat Rev Rheumatol. 2022 May 13. doi: 10.1038/s41584-022-00789-1. Epub ahead of print. PMID: 35562426
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Edward JA, Josey K, Bahn G, Caplan L, Reusch JEB, Reaven P, Ghosh D, Raghavan S. Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis. Cardiovasc Diabetol. 2022 Apr 27;21(1):58. doi: 10.1186/s12933-022-01496-7. PMID: 35477454
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Raghavan S, Warsavage T, Liu WG, Raffle K, Josey K, Saxon DR, Phillips LS, Caplan L, Reusch JEB. Trends in Timing of and Glycemia at Initiation of Second-line Type 2 Diabetes Treatment in U.S. Adults. Diabetes Care. 2022 Mar 28:dc212492. doi: 10.2337/dc21-2492. Epub ahead of print. PMID: 35344584
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Carvajal Bedoya G, Caplan L, Christopher KL, Reddy AK, Ifantides C. Tattoo Granulomas With Uveitis. J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620975968. doi: 10.1177/2324709620975968. PMCID: PMC7705285. PMID: 33238758

Raghavan S, Liu WG, Berkowitz SA, Barón AE, Plomondon ME, Maddox TM, Reusch JEB, Ho PM, Caplan L. Association of Glycemic Control Trajectory with Short-Term Mortality in Diabetes Patients with High Cardiovascular Risk: a Joint Latent Class Modeling Study. J Gen Intern Med. 2020 Aug;35(8):2266-2273. doi: 10.1007/s11606-020-05848-5. Epub 2020 Apr 24. PMCID: PMC7403288. PMID: 32333313

Daniel CM, Davila L, Makris UE, Mayo H, Caplan L, Davis L, Solow EB. Ethnic Disparities in Atherosclerotic Cardiovascular Disease Incidence and Prevalence Among Rheumatoid Arthritis Patients in the United States: a Systematic Review. ACR Open Rheumatol. 2020 Sep;2(9):525-532. doi: 10.1002/acr2.11170. Epub 2020 Sep 1. PMID: 32869533

Sen R, Caplan L. The Never-Ending Conflict (of Interest). Arthritis Rheumatol. 2020 Sep;72(9):1412-1414. doi: 10.1002/art.41394. Epub 2020 Jul 21. PMID: 32524736

Hirsh J, Wood P, Keniston A, Boyle D, Quinzanos I, Caplan L, Davis L. Universal Health Literacy Precautions Are Associated With a Significant Increase in Medication Adherence in Vulnerable Rheumatology Patients. ACR Open Rheumatol. 2020 Feb;2(2):110-118. doi: 10.1002/acr2.11108. Epub 2020 Jan 19. PMID: 31957348



Dill S, Brees K, Stahly A, Cheng E, Carpenter J, Caplan L. Mechanical Shock During Shipping of Medications: The Roles of Packaging and Transportation Vendors. J Pharm Sci. 2020 Jan;109(1):670-676. doi: 10.1016/j.xphs.2019.10.050. Epub 2019 Oct 31. PMID: 31678248

Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L. 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis Care Res (Hoboken). 2019 Oct;71(10):1285-1299. doi: 10.1002/acr.24025. Epub 2019 Aug 21. PMCID: PMC6764857. PMID: 31436026

Farahi JM, Lynn D, Anand P, Walsh JA, Hashim M, Duong R, Dellavalle RP, Reimold A, Kerr GS, Richards JS, Chang E, Kaushik P, Dubreuil M, Caplan L. A prospective cross-sectional analysis of construct validity for the PALMPASS, a brief patient-reported outcome measure for psoriasis. J Psoriasis Psoriatic Arthritis. 2019; 4(4) Online ISSN: 2475-5311

England BR, Duryee MJ, Roul P, Mahajan TD, Singh N, Poole JA, Ascherman DP, Caplan L, Demoruelle MK, Deane KD, Klassen LW, Thiele GM, Mikuls TR. Malondialdehyde-Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis-Associated Interstitial Lung Disease. Arthritis Rheumatol. 2019 Sep;71(9):1483-1493. doi: 10.1002/art.40900. Epub 2019 Jul 22. PMCID: PMC6717041. PMID: 30933423

Coit P, Kaushik P, Caplan L, Kerr GS, Walsh JA, Dubreuil M, Reimold A, Sawalha AH. Genome-wide DNA methylation analysis in ankylosing spondylitis identifies HLA-B*27 dependent and independent DNA methylation changes in whole blood. J Autoimmun. 2019 Aug;102:126-132. doi: 10.1016/j.jaut.2019.04.022. Epub 2019 May 23. PMID: 31128893

Hirsh J, Wood P, Keniston A, Peng M, Ramaswami S, Caplan L, Davis L. Limited Health Literacy and Patient Confusion About Rheumatoid Arthritis Patient Global Assessments and Model Disease States. Arthritis Care Res (Hoboken). 2019 May;71(5):611-619. doi: 10.1002/acr.23692. Epub 2019 Apr 10. PMID: 29953748

Maloley PM, England BR, Sayles H, Thiele GM, Michaud K, Sokolove J, Cannon GW, Reimold AM, Kerr GS, Baker JF, Caplan L, Case AJ, Mikuls TR. Post-traumatic stress disorder and serum cytokine and chemokine concentrations in patients with rheumatoid arthritis✰. Semin Arthritis Rheum. 2019 Oct;49(2):229-235. doi: 10.1016/j.semarthrit.2019.02.002. Epub 2019 Feb 8. PMCID: PMC6687567. PMID: 30777365

Wood PR, Caplan L. Outcomes, Satisfaction, and Costs of a Rheumatology Telemedicine Program: A Longitudinal Evaluation. J Clin Rheumatol. 2019 Jan;25(1):41-44. doi: 10.1097/RHU.0000000000000778. PMID: 30461466