COIN Investigators & Staff
COIN Investigators
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Margaret A. Fitzpatrick, MD, MS
- Title: Infectious Diseases Physician
Associate Professor of Medicine, Division of Infectious Diseases, University of Colorado - Contact: margaret.fitzpatrick@va.gov
- Location: Denver
- University of Colorado webpage
- See Dr. Fitzpatrick's Dimensions profile that includes: publications, grants, datasets, patents and clinical trials
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My research interests include multi-drug resistant and healthcare-associated infections and antimicrobial stewardship in high-risk special patient populations, particularly those with chronic neurologic injury. My research interests also encompass patient-reported outcomes related to infectious diseases and antimicrobial use.
Morbidity and mortality related to multi-drug resistant and healthcare-associated infections remains high, and has increased during the COVID-19 pandemic. Veterans with chronic neurologic injuries and other rehabilitation needs are high risk for these infections. Effective prevention of such infections through judicious use of antibiotics and other strategies is critical.
My current work focuses on improving management of urinary tract infections (UTIs) in patients with bladder dysfunction due to chronic neurologic diseases. We hope to design and intervention to optimize UTI management via improved patient-provider communication and patient recognition and understanding of UTI signs and symptoms. Improved UTI management leads to more appropriate diagnosis and antibiotic use which, in turn, improves rehabilitative health, reduces illness and disability from infections and antibiotic side effects, and optimizes quality of life for high priority Veteran populations.
The following images visualize Dr. Fitzpatrick's work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):
| Publications | Grants |
|---|---|
| Infectious Diseases | Aging |
| Prevention | Injury (total) Accidents/Adverse Effects |
| Clinical Research | Neurosciences |
| Emerging Infectious Diseases | Clinical Research |
| Antimicrobial Resistance | Rehabilitation |
| Vaccine Related | Infectious Diseases |
| Biodefense | Neurodegenerative |
| Dental/Oral and Craniofacial Disease | Urologic Diseases |
| Neurodegenerative | |
| Injury (total) Accidents/Adverse Effects |
Grants & Funding
Optimizing Management of Urinary Tract Infections in Patients with Neurogenic Bladder through Improved Knowledge of Provider Practice and Patient-reported Outcomes
Role: PI
The research in this CDA2 proposal will address fundamental gaps in knowledge about [how to optimize the] management of urinary tract infections (UTIs), which are one of the most common complications experienced by Veterans with chronic neurologic disorders that affect bladder functioning (`neurogenic bladder'). Inappropriate UTI management causes diminished patient functioning and quality of life through adverse effects of improper antibiotic use.
My project will support the development of a novel multifaceted patient-centered intervention to improve UTI management in patients with neurogenic bladder.
Such an intervention could optimize UTI management via improved patient-provider communication and patient recognition and understanding of UTI signs and symptoms. Improved UTI management leads to more appropriate diagnosis and antibiotic use which, in turn, improves rehabilitative health, reduces illness and disability from infections and antibiotic side effects, and optimizes the quality of life for these high-priority Veteran populations.
Funder: Veterans Affairs
NIH website
Publications of Note:
— Clostridioides difficile infection following dental antibiotic prescriptions in a cohort of US veterans
— Treatment of Extensively-drug Resistant (XDR) Acinetobacter and Impact on Clinical Outcomes in U.S. Veterans Affairs (VA) Medical Centers
— Antibiotic prophylaxis prescriptions prior to dental visits in the Veterans’ Health Administration (VHA), 2015–2019
Combating Antimicrobial Resistance through Rapid Implementation of Available Guidelines and Evidence 2.0 (CARRIAGE 2.0)
Role: C0-I
Funder: Veterans Affairs, HSR&D Quality Enhancement Research Initiative (QUERI)
Improving Veteran health by increasing dental stewardship of antibiotics and opioids
Role: C0-I
Funder: Veterans Affairs, HSR&D
Effectiveness of treatment and outcomes for Veterans infected with resistant Gram-negative organisms
Role: C0-I
Funder: Veterans Affairs, HSR&D
Antimicrobial Stewardship Program Implementation in a Specialized Population
Role: C0-I
Funder: Midwest Roybal Center for Health Promotion and Translation UIC
Data MIME: Data Model for Initiatives to Monitor Exposure to Antimicrobials in PCORNet and Sentinel
Role: Site PI
Funder: PCORI
Recent Publications
2023
Wirth M, Suda KJ, Burns SP, Weaver FM, Collins E, Safdar N, Kartje R, Evans CT, Fitzpatrick MA. A retrospective cohort study of patient-reported urinary tract infection signs and symptoms among individuals with neurogenic bladder. Am J Phys Med Rehabil. 2023 Mar 15. doi: 10.1097/PHM.0000000000002204. Epub ahead of print.
PMID: 36927768
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2022
Fitzpatrick MA, Wirth M, Nguyen J, Suda KJ, Weaver FM, Burns S, Collins E, Safdar N, Patel U, Evans CT. Clinical outcomes associated with guideline-discordant management of asymptomatic bacteriuria and urinary tract infection in hospitalized patients with neurogenic bladder. Antimicrob Steward Healthc Epidemiol. 2022 Dec 9;2(1):e195. doi: 10.1017/ash.2022.348. PMCID: PMC9879921.
PMID: 36712473
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Wilson GM, Fitzpatrick MA, Suda KJ, Smith BM, Gonzalez B, Jones M, Schweizer ML, Evans M, Evans CT. Comparative effectiveness of antibiotic therapy for carbapenem-resistant Enterobacterales (CRE) bloodstream infections in hospitalized US veterans. JAC Antimicrob Resist. 2022 Oct 26;4(5):dlac106. doi: 10.1093/jacamr/dlac106. PMCID: PMC9596539.
PMID: 36320448
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Ramanathan S, Albarillo FS, Fitzpatrick MA, Suda KJ, Poggensee L, Vivo A, Evans ME, Jones M, Safdar N, Pfeiffer C, Smith B, Wilson G, Evans CT. Infectious Disease Consults of Pseudomonas aeruginosa Bloodstream Infection and Impact on Health Outcomes. Open Forum Infect Dis. 2022 Sep 9;9(9):ofac456. doi: 10.1093/ofid/ofac456. PMCID: PMC9511117.
PMID: 36168551
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Evans CT, Fitzpatrick MA, Poggensee L, Gonzalez B, Gibson G, Jurasic MM, Echevarria K, McGregor JC, Gellad WF, Suda KJ. High Prescribing of Antibiotics is Associated with High Prescribing of Opioids in Medical and Dental Providers. Pharmacotherapy. 2022 Jul 22. doi: 10.1002/phar.2720. Epub ahead of print.
PMID: 35869691
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Fitzpatrick MA, Suda KJ, Ramanathan S, Wilson G, Poggensee L, Evans M, Jones MM, Pfeiffer CD, Klutts JS, Perencevich E, Rubin M, Evans CT; QUERI CARRIAGE Program. Increased carbapenemase testing following implementation of national VA guidelines for carbapenem-resistant Enterobacterales (CRE). Antimicrob Steward Healthc Epidemiol. 2022 Jun 2;2(1):e88. doi: 10.1017/ash.2021.220. PMCID: PMC9726513.
PMID: 36483386
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Hughes AM, Evans CT, Fitzpatrick MA, Kale IO, Vivo A, Boyer TL, Solanki PA, Gibson G, Jurasic MM, Sharp LK, Echevarria KL, Suda KJ. A qualitative approach to examining antimicrobial prescribing in the outpatient dental setting. Antimicrob Steward Healthc Epidemiol. 2022 Jun 24;2(1):e102. doi: 10.1017/ash.2022.242. PMCID: PMC9726505.
PMID: 36483419
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Vivo A, Durkin MJ, Kale I, Boyer T, Fitzpatrick MA, Evans CT, Jurasic MM, Gibson G, Suda KJ. Opportunities for penicillin allergy evaluation in dental clinics. Antimicrob Steward Healthc Epidemiol. 2022 Apr 11;2(1):e58. doi: 10.1017/ash.2022.18. PMCID: PMC9726497.
PMID: 36483385
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Vivo A, Fitzpatrick MA, Suda KJ, Jones MM, Perencevich EN, Rubin MA, Ramanathan S, Wilson GM, Evans ME, Evans CT. Epidemiology and outcomes associated with carbapenem-resistant Acinetobacter baumannii and carbapenem-resistant Pseudomonas aeruginosa: a retrospective cohort study. BMC Infect Dis. 2022 May 24;22(1):491. doi: 10.1186/s12879-022-07436-w. PMCID: PMC9128216.
PMID: 35610601
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Suda KJ, Fitzpatrick MA, Gibson G, Jurasic MM, Poggensee L, Echevarria K, Hubbard CC, McGregor JC, Evans CT. Antibiotic prophylaxis prescriptions prior to dental visits in the Veterans' Health Administration (VHA), 2015-2019. Infect Control Hosp Epidemiol. 2022 Feb 22:1-10. doi: 10.1017/ice.2021.521. Epub ahead of print.
PMID: 35189986
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Wilson GM, Evans CT, Fitzpatrick MA, Poggensee L, Gibson G, Jurasic MM, Echevarria K, Suda KJ. Clostridioides difficile infection following dental antibiotic prescriptions in a cohort of US veterans. Infect Control Hosp Epidemiol. 2022 Feb 21:1-3. doi: 10.1017/ice.2021.516. Epub ahead of print.
PMID: 35188097
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Fitzpatrick MA, Suda KJ, Poggensee L, Vivo A, Wilson G, Jones MM, Evans M, Safdar N, Evans CT. Treatment of extensively-drug resistant (XDR) Acinetobacter and impact on clinical outcomes in U.S. veterans affairs (VA) medical centers. Am J Infect Control. 2022 Jan 30:S0196-6553(22)00052-9. doi: 10.1016/j.ajic.2022.01.011. Epub ahead of print.
PMID: 35108579
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