Seattle-Denver Center of Innovation (COIN)

COIN Investigators & Staff

COIN Investigators

P. Michael Ho, MD, PhD

Title: Core Investigator
Professor, University of Colorado School of Medicine; Vice Chair for Quality, Department of Medicine

2021 HSR Health System Impact Awardee

Contact: Michael.Ho@va.gov

Location: Denver

University of Colorado webpage

See Dr. Ho's Dimensions profile that includes: publications, grants, datasets, patents and clinical trials

Dr. Ho is Professor of Medicine at the University of Colorado and cardiologist at the Rocky Mountain Regional VA Medical Center. He was an HSR Career Development Awardee (CDA) and has been an active investigator within the Denver HSR Center since 2004. Dr. Ho co-directs the Seattle-Denver Center of Innovation for Veteran-Centered and Value Driven Care along with David Au, MD.

His research has focused on medication adherence and interventions to improve medication adherence. More recently, his research has focused on value in healthcare and creating learning health systems to improve the value of health care delivered to patients. He co-leads the VA Collaborative Evaluation (VACE) team which is focused on conducting collaborative program evaluations with VA clinical and operational partners. These evaluation findings have led to policy changes and clinical program improvement within VA. He serves in several leadership positions on national cardiology organizations for the American Heart Association (AHA) and the American College of Cardiology.

The following images visualize Dr. Ho's work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):

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Grants & Funding

Personalized Patient data and behavioral nudges to improve adherence to chronic cardiovascular medications

Given the increasing prevalence of chronic diseases that require ongoing treatment with medications, the problem of medication non-adherence is unlikely to go away and will grow.
This study will employ population-level pharmacy data to identify non-adherent patients and utilize ubiquitous cell phone technology to send them tailored, engaging, and motivating text messages and text message-based chat through an artificially intelligent (AI) interactive chatbot to improve cardiac medication adherence and patient outcomes in 3 integrated healthcare delivery systems.
This study will advance medication adherence research. The intervention could be applied to multiple clinical conditions requiring medications for long-term treatment at other NIH institutes.
Funder: National Heart, Lung, and Blood Institute
NIH website
Publications of note:
Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies
Leave me out: Patients’ characteristics and reasons for opting out of a pragmatic clinical trial involving medication adherence
Text Message Medication Adherence Reminders Automated and Delivered at Scale Across Two Institutions: Testing the “Nudge” System: Pilot study
The NUDGE trial pragmatic trial to enhance cardiovascular medication adherence: study protocol for a randomized controlled trial

Appropriate Use of Cardiovascular Procedures to Optimize Healthcare Value

Enhancing value by achieving optimal patient outcomes at lower total care costs represents an overarching goal for healthcare delivery. One potential contributor to low-value care is using diagnostic tests and procedures among patients without anticipated procedural benefits. According to the Appropriate Use Criteria, inappropriate use is the use of diagnostic and therapeutic procedures, which result in unnecessary clinical risks and healthcare costs.
Little data is available on the extent of inappropriate use of healthcare in the VA. Our work will determine the size and impact of inappropriate use of cardiac procedures on healthcare value among patients with stable coronary artery disease, a common and high-cost clinical problem.
Further, we will conduct qualitative research to identify best practices for appropriate procedural use and high-value healthcare. The findings of our proposal inform strategies to reduce costs of care while maintaining optimal patient outcomes in high-utilization, high-cost care delivery.
Funder: Veterans Affairs
NIH website

Value-Based Care to Improve the Quadruple Aim for Veterans and Stakeholders

Role: Co-PI with Joe Frank PI is Catherine Battaglia
The Quadruple Aim Quality Enhancement Research Initiative (QUERI) aims to improve the care and experience for Veterans, clinician engagement, and reduce the cost of care. We will improve care coordination between Veterans Health Administration (VA) and community settings for Veterans using three evidence-based practices rooted in care coordination models to achieve consistently safe, efficient, and effective care for Veterans who are:
1) referred to home health care after discharge from VA,
2) receiving medication treatment for Opioid Use Disorders in the community, and
3) hospitalized or receiving emergency care in the community and return to VA or VA-assigned community PCP for ongoing care.
Veterans with complex medical and social needs will be case managed by a multidisciplinary team to ensure timely access to care and linkage to resources. The Quadruple Aim QUERI will improve health with optimal patient and clinician experience at a lower cost.
Funder: Veterans Affairs
NIH website

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Recent Publications

2024

Hess PL, Langner P, Heidenreich PA, Essien U, Leonard C, Swat SA, Polsinelli V, Orlando ST, Grunwald GK, Ho PM. National Trends in Hospital Performance in Guideline-Recommended Pharmacologic Treatment for Heart Failure at Discharge. JACC Heart Fail. 2024 Mar 23:S2213-1779(24)00178-1. doi: 10.1016/j.jchf.2024.02.014. Epub ahead of print.
PMID: 38573268.
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Leppert MH, Poisson SN, Scarbro S, Suresh K, Lisabeth LD, Putaala J, Schwamm LH, Daugherty SL, Bradley CJ, Burke JF, Ho PM. Association of Traditional and Nontraditional Risk Factors in the Development of Strokes Among Young Adults by Sex and Age Group: A Retrospective Case-Control Study. Circ Cardiovasc Qual Outcomes. 2024 Mar 26:e010307. doi: 10.1161/CIRCOUTCOMES.123.010307. Epub ahead of print.
PMID: 38529631
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Dunbar PJ, Peterson R, McGrath M, Pomponio R, Kiser TH, Ho PM, Vandivier RW, Burnham EL, Moss M, Sottile PD; Colorado Pulmonary Outcomes Research Group. Analgesia and Sedation Use During Noninvasive Ventilation for Acute Respiratory Failure. Crit Care Med. 2024 Mar 20. doi: 10.1097/CCM.0000000000006253. Epub ahead of print.
PMID: 38506571
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Leonard C, Carey E, Holstein A, Ho PM, Heckman JT. Cluster-randomized implementation trial of two facilitation strategies to implement a novel information and communications technology at the Veterans Health Administration. Implement Sci. 2024 Jan 2;19(1):1. doi: 10.1186/s13012-023-01329-5. PMCID: PMC10759444.
PMID: 38166974
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2023

Zigler CK, Adeyemi O, Boyd AD, Braciszewski JM, Cheville A, Cuthel AM, Dailey DL, Del Fiol G, Ezenwa MO, Faurot KR, Justice M, Ho PM, Lawrence K, Marsolo K, Patil CL, Paek H, Richesson RL, Staman KL, Schlaeger JM, O'Brien EC. Collecting patient-reported outcome measures in the electronic health record: Lessons from the NIH pragmatic trials Collaboratory. Contemp Clin Trials. 2023 Dec 30;137:107426. doi: 10.1016/j.cct.2023.107426. Epub ahead of print.
PMID: 38160749
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Salahuddin T, Hebbe A, Daus M, Essien UR, Waldo SW, Rodriguez F, Ho PM, Simons C, Gilmartin HM, Doll JA. Trends and Site-level Variation of Novel Cardiovascular Medication Utilization among Patients Admitted for Heart Failure or Coronary Artery Disease in the US Veterans Affairs System: 2017-2021. Am Heart J. 2023 Nov 11:S0002-8703(23)00318-6. doi: 10.1016/j.ahj.2023.11.009. Epub ahead of print.
PMID: 37956920
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Abera SM, O'Donnell C, Salahuddin T, Prabhu K, Simons CE, Ho PM, Waldo SW, Doll JA. Assessment of Medication Adherence Using Pharmacy Data Before and After Percutaneous Coronary Intervention. Patient Prefer Adherence. 2023 Nov 3;17:2789-2795. doi: 10.2147/PPA.S431183. PMCID: PMC10629403.
PMID: 37942121.
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Sandhu A, Kaltenbach LA, Chiswell K, Shimoga V, Ashur C, Pribish A, Fonarow GC, Piccini JP, Ho PM, Varosy PD, Hess PL. Off-Label Dosing of Direct Oral Anticoagulants Among Inpatients with Atrial Fibrillation in the United States. Circ Cardiovasc Qual Outcomes. 2023 Nov 6. doi: 10.1161/CIRCOUTCOMES.123.010062. Epub ahead of print.
PMID: 37929603.
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Kovach CP, Mesenbring EC, Gupta P, Glorioso TJ, Ho PM, Waldo SW, Schwartz GG. Projected Outcomes of Optimized Statin and Ezetimibe Therapy in US Military Veterans with Coronary Artery Disease. JAMA Netw Open. 2023 Aug 1;6(8):e2329066. doi: 10.1001/jamanetworkopen.2023.29066.
PMID: 37638630.
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Manning E, Ho M, Sandhu A. Response to Letter to the Editor regarding Factors associated with oral anticoagulant prescription status among patients with a new diagnosis of atrial fibrillation. Clin Cardiol. 2023 Aug 15. doi: 10.1002/clc.24122. Epub ahead of print.
PMID: 37583247.
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Swat SA, Helmkamp LJ, Tietbohl C, Thompson JS, Fitzgerald M, McIlvennan CK, Harger G, Ho PM, Ahmad FS, Ahmad T, Buttrick P, Allen LA. Clinical Inertia Among Outpatients With Heart Failure: Application of Treatment Nonintensification Taxonomy to EPIC-HF Trial. JACC Heart Fail. 2023 Jul 31:S2213-1779(23)00375-X. doi: 10.1016/j.jchf.2023.06.022. Epub ahead of print.
PMID: 37589610.
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Sandhu AT, Heidenreich PA, Borden W, Farmer SA, Ho PM, Hammond G, Johnson JC, Wadhera RK, Wasfy JH, Biga C, Takahashi E, Misra KD, Joynt Maddox KE; American Heart Association Advocacy Coordinating Committee. Value-Based Payment for Clinicians Treating Cardiovascular Disease: A Policy Statement From the American Heart Association. Circulation. 2023 Jul 10. doi: 10.1161/CIR.0000000000001143. Epub ahead of print.
PMID: 37427456.
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Manning E, Burns K, Laurie M, Patten L, Ho M, Sandhu A. Factors associated with oral anticoagulant prescription status among patients with a new diagnosis of atrial fibrillation. Clin Cardiol. 2023 Jul 4. doi: 10.1002/clc.24077. Epub ahead of print.
PMID: 37401357.
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Derington CG, Goodrich GK, Xu S, Clark NP, Reynolds K, An J, Witt DM, Smith DH, O'Keeffe-Rosetti M, Lang DT, Ho PM, Cheetham TC, Comer AC, King JB. Association of Direct Oral Anticoagulation Management Strategies With Clinical Outcomes for Adults With Atrial Fibrillation. JAMA Netw Open. 2023 Jul 3;6(7):e2321971. doi: 10.1001/jamanetworkopen.2023.21971. PMCID: PMC10326649.
PMID: 37410461.
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Ebinger JE, Gluckman TJ, Magraner J, Chiu ST, Rider D, Thomas C, Das SR, Ho PM, Shreenivas S, Bradley S. Characterization of Individuals With Apparent Resistant Hypertension Using Contemporary Guidelines: Insights From CV-QUIC. Hypertension. 2023 Jun 26. doi: 10.1161/HYPERTENSIONAHA.123.20894. Epub ahead of print.
PMID: 37357771.
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Boyd AD, Gonzalez-Guarda R, Lawrence K, Patil CL, Ezenwa MO, O'Brien EC, Paek H, Braciszewski JM, Adeyemi O, Cuthel AM, Darby JE, Zigler CK, Ho PM, Faurot KR, Staman KL, Leigh JW, Dailey DL, Cheville A, Del Fiol G, Knisely MR, Grudzen CR, Marsolo K, Richesson RL, Schlaeger JM. Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory. J Am Med Inform Assoc. 2023 Jun 26:ocad115. doi: 10.1093/jamia/ocad115. Epub ahead of print.
PMID: 37364017.
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Waughtal J, Glorioso TJ, Sandy LM, Peterson PN, Chavez C, Bull S, Ho PM, Allen LA. Patient engagement with prescription refill text reminders across time and major societal events. Cardiovasc Digit Health J. 2023 Jun 14;4(4):133-136. doi: 10.1016/j.cvdhj.2023.06.002. PMCID: PMC10290239.
PMID: 37600444.
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Marrs JC, Orlando ST, Saseen JJ, Novins-Montague S, Sandy LC, Waughtal J, Glorioso TJ, Ho PM. Description of patient questions received by clinical pharmacists in the Nudge Study. Am J Health Syst Pharm. 2023 Jun 23:zxad139. doi: 10.1093/ajhp/zxad139. Epub ahead of print.
PMID: 37353220.
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Dodge JR, Youles B, Caldararo J, Sears ED, Caverly TJ, Michael Ho P, Shimada SL, Kaboli P, Albright K, Robinson SA, McNeal DM, Damschroder L, Saini SD, Adams MA. Engaging Operational Partners Is Critical for Successful Implementation of Research Products: a Coincidence Analysis of Access-Related Projects in the Veterans Affairs Healthcare System. J Gen Intern Med. 2023 Jun 20. doi: 10.1007/s11606-023-08115-5. Epub ahead of print.
PMID: 37340262.
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Boyd AD, Gonzalez-Guarda R, Lawrence K, Patil CL, Ezenwa MO, O'Brien EC, Paek H, Braciszewski JM, Adeyemi O, Cuthel AM, Darby JE, Zigler CK, Ho PM, Faurot KR, Staman K, Leigh JW, Dailey DL, Cheville A, Del Fiol G, Knisely MR, Marsolo K, Richesson RL, Schlaeger JM. Equity and bias in electronic health records data. Contemp Clin Trials. 2023 May 22;130:107238. doi: 10.1016/j.cct.2023.107238. Epub ahead of print.
PMID: 37225122.
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Mistry N, Richardson V, Carey E, Porter S, Pincus S, Novins-Montague S, Elmer M, Lin CT, Ho PM, Anstett T. General improvements versus interruptive or non-interruptive alerts in the blood order set: study protocol for a randomized control trial to improve packed red blood cell utilization. Trials. 2023 May 8;24(1):314. doi: 10.1186/s13063-023-07319-8. PMCID: PMC10165805.
PMID: 37158929.
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Rolfzen ML, Wick A, Mascha EJ, Shah K, Krause M, Fernandez-Bustamante A, Kutner JS, Ho PM, Sessler DI, Bartels K. Best Practice Alerts Informed by Inpatient Opioid Intake to Reduce Opioid Prescribing After Surgery (PRIOR) - A Cluster Randomized Multiple Crossover Trial. Anesthesiology. 2023 May 8. doi: 10.1097/ALN.0000000000004607. Epub ahead of print.
PMID: 37155372.
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Reynolds PM, Afshar M, Wright GC, Ho PM, Kiser TH, Sottile PD, Althoff MD, Moss M, Jolley SE, Vandivier RW, Burnham EL. Association between Substance Misuse and Outcomes in Critically III Patients with Pneumonia. Ann Am Thorac Soc. 2023 Apr;20(4):556-565. doi: 10.1513/AnnalsATS.202206-532OC.
PMID: 37000145.
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Gupta P, Sandy LC, Glorioso TJ, Khanna A, Khazanie P, Allen LA, Peterson PN, Bull S, Ho PM. Secondary Analysis of Electronic Opt-Out Consent in Pragmatic Research: A Study Design Method to Diversify Clinical Trials? Am Heart J. 2023 Mar 24:S0002-8703(23)00071-6. doi: 10.1016/j.ahj.2023.03.010. Epub ahead of print.
PMID: 36966921.
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Abbate LM, Ollerenshaw LV, Kottmeyer BM, McQuown CM, Ragsdale LC, Richardson VL, Ho PM, Ginde AA, O'Malley SM. Integrating Physical Therapy into an Emergency Department: A Clinical Pilot Program. Acad Emerg Med. 2023 Mar 13. doi: 10.1111/acem.14707. Epub ahead of print.
PMID: 36912801.
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Sterbis E, Lindquist J, Jensen A, Hong M Jr, Gupta S, Ryu R, Ho PM, Trivedi P. Inferior Vena Cava Filter Retrieval Rates Associated With Passive and Active Surveillance Strategies Adopted by Implanting Physicians. JAMA Netw Open. 2023 Mar 1;6(3):e233211. doi: 10.1001/jamanetworkopen.2023.3211. PMCID: PMC10020881.
PMID: 36929400.
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Stryczek KC, Honsberger M, Ball SL, Barnard JG, Young JP, Felker B, Au DH, Ho PM, Kirsh SR, Sayre GG. VA Outreach Is an Essential Area for Improving Veterans' Health Care Accessibility. Mil Med. 2023 Feb 15:usad019. doi: 10.1093/milmed/usad019. Epub ahead of print.
PMID: 36790439.
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Weisbord SD, Mor MK, Hochheiser H, Kim N, Ho PM, Bhatt DL, Fine MJ, Palevsky PM. Utilization and Outcomes of Clinically Indicated Invasive Cardiac Care in Veterans with Acute Coronary Syndrome and Chronic Kidney Disease. J Am Soc Nephrol. 2023 Jan 5. doi: 10.1681/ASN.0000000000000067. Epub ahead of print. PMID: 36735537
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Morse B, Anstett T, Mistry N, Porter S, Pincus S, Lin CT, Novins-Montague S, Ho PM. User-Centered Design to Reduce Inappropriate Blood Transfusion Orders. Appl Clin Inform. 2023 Jan;14(1):28-36. doi: 10.1055/s-0042-1759866. Epub 2023 Jan 11. PMCID: PMC9833954. PMID: 36630999
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2022

Henderson K, Kaufman B, Rotter JS, Stearns S, Sueta CAA, Foraker R, Ho PM, Chang PP. Socioeconomic status and modification of atherosclerotic cardiovascular disease risk prediction: epidemiological analysis using data from the atherosclerosis risk in communities study. BMJ Open. 2022 Nov 7;12(11):e058777. doi: 10.1136/bmjopen-2021-058777. PMID: 36343998
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Zakrajsek JK, Min SJ, Ho PM, Kiser TH, Kannappan A, Sottile PD, Allen RR, Althoff MD, Reynolds PM, Moss M, Burnham EL, Mikkelsen ME, Vandivier RW. Extracorporeal Membrane Oxygenation (ECMO) for Refractory Asthma Exacerbations with Respiratory Failure. Chest. 2022 Sep 30:S0012-3692(22)03899-5. doi: 10.1016/j.chest.2022.09.029. Epub ahead of print. PMID: 36191634
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Subramaniam S, Stryczek KC, Ball S, Stevenson L, Ho PM, Aron DC. Workforce Development to Improve Access to Pain Care for Veterans: A Qualitative Analysis of VA-ECHO Participant Experiences. Health Serv Res Manag Epidemiol. 2022 Sep 7;9:23333928221124806. doi: 10.1177/23333928221124806. PMCID: PMC9452798. PMID: 36093259
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Maw AM, Morris MA, Glasgow RE, Barnard J, Ho PM, Ortiz-Lopez C, Fleshner M, Kramer HR, Grimm E, Ytell K, Gardner T, Huebschmann AG. Using Iterative RE-AIM to enhance hospitalist adoption of lung ultrasound in the management of patients with COVID-19: an implementation pilot study. Implement Sci Commun. 2022 Aug 12;3(1):89. doi: 10.1186/s43058-022-00334-x. PMCID: PMC9372925. PMID: 35962441
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Trivedi PS, Timpone VM, Morgan RL, Jensen AM, Reid M, Ho PM, Ahmed O. A Practical Guide to Use of Publicly Available Datasets for Observational Research in Interventional Radiology. J Vasc Interv Radiol. 2022 Aug 11:S1051-0443(22)01124-1. doi: 10.1016/j.jvir.2022.08.003. Epub ahead of print. PMID: 35964883
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Anstett T, Smith CR, Hess K, Patten L, Pincus S, Lin CT, Ho PM. CIC 2021: Dig Deeper: A Case Report of Finding (and fixing) the Root Cause of Add-On Laboratory Failures. Appl Clin Inform. 2022 Jul 29. doi: 10.1055/a-1913-4158. Epub ahead of print. PMID: 35913087
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Trinkley KE, Ho PM, Glasgow RE, Huebschmann AG. How Dissemination and Implementation Science Can Contribute to the Advancement of Learning Health Systems. Acad Med. 2022 Jul 5. doi: 10.1097/ACM.0000000000004801. Epub ahead of print. PMID: 35796045
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Mog AC, Moldestad M, Kenney R, Stevenson L, Lee M, Ho PM, Sayre GG. "I was Unsure at First": A Qualitative Evaluation of Patient Perceptions of VA Clinical Video Telehealth Visits in the V-IMPACT Program. J Patient Exp. 2022 Jul 3;9:23743735221107237. doi: 10.1177/23743735221107237. PMCID: PMC9260561. PMID: 35813242
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Ho PM, O'Donnell CI, McCreight M, Bavry AA, Bosworth HB, Girotra S, Grossman PM, Helfrich C, Latif F, Lu D, Matheny M, Mavromatis K, Ortiz J, Parashar A, Ratliff DM, Grunwald GK, Gillette M, Jneid H. Multifaceted Intervention to Improve P2Y12 Inhibitor Adherence After Percutaneous Coronary Intervention: A Stepped Wedge Trial. J Am Heart Assoc. 2022 Jun 29:e024342. doi: 10.1161/JAHA.121.024342. Epub ahead of print. PMID: 35766258
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Kini V, Parks M, Liu W, Waldo SW, Ho PM, Bradley SM, Hess PL. Patient Symptoms and Stress Testing After Elective Percutaneous Coronary Intervention in the Veterans Affairs Health Care System. JAMA Netw Open. 2022 Jun 1;5(6):e2217704. doi: 10.1001/jamanetworkopen.2022.17704. PMID: 35727581
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Parks M, Nallamothu B, Ho PM. Not So Simple, Nor Model Minority. Circ Cardiovasc Qual Outcomes. 2022 May;15(5):e008918. doi: 10.1161/CIRCOUTCOMES.122.008918. Epub 2022 May 10. PMID: 35535590
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McNeal DM, Fehling K, Ho PM, Kaboli P, Shimada S, Saini SD, Youles B, Albright K. Engaging Stakeholders in Identifying Access Research Priorities for the Department of Veterans Affairs. J Gen Intern Med. 2022 Mar 29. doi: 10.1007/s11606-021-07195-5. Epub ahead of print. PMID: 35349024
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Kini V, Breathett K, Groeneveld PW, Ho PM, Nallamothu BK, Peterson PN, Rush P, Wang TY, Zeitler EP, Borden WB; American Heart Association Council on Quality of Care and Outcomes Research. Strategies to Reduce Low-Value Cardiovascular Care: A Scientific Statement From the American Heart Association. Circ Cardiovasc Qual Outcomes. 2022 Feb 22:HCQ0000000000000105. doi: 10.1161/HCQ.0000000000000105. Epub ahead of print. PMID: 35189687
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Waldo SW, Glorioso TJ, Barón AE, Doll JA, Plomondon ME, Ho PM. Transitions of Care Among Patients Undergoing Percutaneous Coronary Intervention for Stable Angina: Insights From the Veterans Affairs Clinical Assessment Reporting and Tracking Program. J Am Heart Assoc. 2022 Feb 15;11(4):e024598. doi: 10.1161/JAHA.121.024598. Epub 2022 Feb 12. PMID: 35156396
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Leppert MH, Burke JF, Lisabeth LD, Madsen TE, Kleindorfer DO, Sillau S, Schwamm LH, Daugherty SL, Bradley CJ, Ho PM, Poisson SN. Systematic Review of Sex Differences in Ischemic Strokes Among Young Adults: Are Young Women Disproportionately at Risk? Stroke. 2022 Feb;53(2):319-327. doi: 10.1161/STROKEAHA.121.037117. Epub 2022 Jan 24. PMID: 35073188
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Trivedi P, Jordan G, Ho PM. Leveraging Value-Based Payment Models to Reduce Health Inequities in Radiology. J Am Coll Radiol. 2022 Jan;19(1 Pt B):143-145. doi: 10.1016/j.jacr.2021.09.021. PMID: 35033302
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Leonard C, Kenney RR, Lee M, Greene P, Whittington M, Kirsh S, Ho PM, Sayre G, Simonetti J. Common Ground: Primary Care and Specialty Clinicians' Perceptions of E-Consults in the Veterans Health Administration. Fed Pract. 2022 Jan;39(1):42-47b. doi: 10.12788/fp.0214. Epub 2022 Jan 12. PMCID: PMC8849031. PMID: 35185320
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2021

Sandy LC, Glorioso TJ, Weinfurt K, Sugarman J, Peterson PN, Glasgow RE, Ho PM. Leave me out: Patients' characteristics and reasons for opting out of a pragmatic clinical trial involving medication adherence. Medicine (Baltimore). 2021 Dec 23;100(51):e28136. doi: 10.1097/MD.0000000000028136. PMCID: PMC8702195.
PMID: 34941059

Rao SS, Jensen AM, Kriss MS, Morgan RL, Ho PM, Ryu RK, Trivedi PS. Racial differences in use of endoscopy and Transjugular Intrahepatic Portosystemic Shunt creation for treatment of acute variceal bleeding in the United States. J Vasc Interv Radiol. 2021 Dec 17:S1051-0443(21)01582-7. doi: 10.1016/j.jvir.2021.12.016. Epub ahead of print.
PMID: 34929343

Lauffenburger JC, Ho PM, Nallamothu BK. Finishing Touches: Enhancing Scientific Communication Through Circulation: Cardiovascular Quality and Outcomes' Technical Review. Circ Cardiovasc Qual Outcomes. 2021 Dec;14(12):e008735. doi: 10.1161/CIRCOUTCOMES.121.008735. Epub 2021 Dec 21.
PMID: 34932379

Levy AE, Whittington MD, Anstett TJ, Simon ST, Wentworth A, Carter JE Jr, Ho PM. A Systems-Based Morbidity and Mortality Conference Was Associated With a Transient Reduction in ECG Completion Times. Qual Manag Health Care. 2021 Oct 29. doi: 10.1097/QMH.0000000000000319. Epub ahead of print.
PMID: 34724456

Sacha GL, Kiser TH, Wright GC, Vandivier RW, Moss M, Burnham EL, Ho PM, Reynolds PM, Bauer SR. Association Between Vasopressin Rebranding and Utilization in Patients With Septic Shock. Crit Care Med. 2021 Oct 4. doi: 10.1097/CCM.0000000000005305. Epub ahead of print.
PMID: 34605778

Richesson RL, Marsolo KS, Douthit BJ, Staman K, Ho PM, Dailey D, Boyd AD, McTigue KM, Ezenwa MO, Schlaeger JM, Patil CL, Faurot KR, Tuzzio L, Larson EB, O'Brien EC, Zigler CK, Lakin JR, Pressman AR, Braciszewski JM, Grudzen C, Fiol GD. Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory. J Am Med Inform Assoc. 2021 Oct 1:ocab202. doi: 10.1093/jamia/ocab202. Epub ahead of print.
PMID: 34597383

Schroeder EB, Neugebauer R, Reynolds K, Schmittdiel JA, Loes L, Dyer W, Pimentel N, Desai JR, Vazquez-Benitez G, Ho PM, Anderson JP, O'Connor PJ. Association of Cardiovascular Outcomes and Mortality With Sustained Long-Acting Insulin Only vs Long-Acting Plus Short-Acting Insulin Treatment. JAMA Netw Open. 2021 Sep 1;4(9):e2126605. doi: 10.1001/jamanetworkopen.2021.26605.
PMID: 34559229

Maw AM, Ho PM, Morris MA, Glasgow RE, Huebschmann AG, Barnard JG, Metter R, Tierney DM, Mathews BK, Havranek EP, Kissler M, Fleshner M, Burian BK, Platz E, Soni NJ. Hospitalist Perceptions of Barriers to Lung Ultrasound Adoption in Diverse Hospital Environments. Diagnostics (Basel). 2021 Aug 11;11(8):1451. doi: 10.3390/diagnostics11081451. PMCID: PMC8391960.
PMID: 34441385

Glasgow RE, Knoepke CE, Magid D, Grunwald GK, Glorioso TJ, Waughtal J, Marrs JC, Bull S, Ho PM. The NUDGE trial pragmatic trial to enhance cardiovascular medication adherence: study protocol for a randomized controlled trial. Trials. 2021 Aug 11;22(1):528. doi: 10.1186/s13063-021-05453-9. PMCID: PMC8356469.
PMID: 34380527

Simon ST, Kini V, Levy AE, Ho PM. Medication adherence in cardiovascular medicine. BMJ. 2021 Aug 11;374:n1493. doi: 10.1136/bmj.n1493.
PMID: 34380627

Bradley SM, Kaltenbach LA, Xiang K, Amin AP, Hess PL, Maddox TM, Poulose A, Brilakis ES, Sorajja P, Ho PM, Rao SV. Trends in Use and Outcomes of Same-Day Discharge Following Elective Percutaneous Coronary Intervention. JACC Cardiovasc Interv. 2021 Aug 9;14(15):1655-1666. doi: 10.1016/j.jcin.2021.05.043.
PMID: 34353597.

Trivedi PS, Jensen AM, Brown MA, Morgan RL, Lindrooth RC, Ryu RK, Ho PM, Kriss MS. High Prevalence of Transjugular Intrahepatic Portosystemic Shunt Creation Without Prior Endoscopy During Acute Variceal Bleeding Hospitalization in the United States. Hepatol Commun. 2021 Jul 1. doi: 10.1002/hep4.1756. Epub ahead of print.
PMID: 34558832.

Maw AM, Morris MA, Barnard JG, Wilson J, Glasgow RE, Huebschmann AG, Soni NJ, Fleshner M, Kaufman J, Ho PM. Multi-Level Stakeholder Perspectives on Determinants of Point of Care Ultrasound Implementation in a US Academic Medical Center. Diagnostics (Basel). 2021 Jun 28;11(7):1172. doi: 10.3390/diagnostics11071172.
PMID: 34203357.

Tuzzio L, Meyers CM, Dember LM, Grudzen CR, Melnick ER, Staman KL, Huang SS, Richards J, DeBar L, Vazquez MA, Green BB, Coronado GD, Jarvik JG, Braciszewski J, Ho PM, Wells BL, James K, Toto R, D'Onofrio G, Volandes A, Kuklinski MR, Catalano RF, Sterling SA, Morse EF, Curtis L, Larson EB. Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies. Healthc (Amst). 2021 Jun;8 Suppl 1:100432. doi: 10.1016/j.hjdsi.2020.100432. Epub 2021 Jun 23.
PMID: 34175091.

Damschroder LJ, Knighton AJ, Griese E, Greene SM, Lozano P, Kilbourne AM, Buist DSM, Crotty K, Elwy AR, Fleisher LA, Gonzales R, Huebschmann AG, Limper HM, Ramalingam NS, Wilemon K, Ho PM, Helfrichfcr CD. Recommendations for strengthening the role of embedded researchers to accelerate implementation in health systems: Findings from a state-of-the-art (SOTA) conference workgroup. Healthc (Amst). 2021 Jun;8 Suppl 1:100455. doi: 10.1016/j.hjdsi.2020.100455.
PMID: 34175093.

Waughtal J, Luong P, Sandy L, Chavez C, Ho PM, Bull S. Nudge me: tailoring text messages for prescription adherence through N-of-1 interviews. Transl Behav Med. 2021 Jun 3:ibab056. doi: 10.1093/tbm/ibab056. Epub ahead of print.
PMID: 34080636.

Hess PL, Gosch KL, Jani SM, Varosy PD, Bradley SM, Maddox TM, Michael Ho P, Virani SS. Use of Oral Anticoagulants in Patients with Valvular Atrial Fibrillation: Findings From the NCDR PINNACLE Registry®. Am Heart J. 2021 May 22:S0002-8703(21)00120-4. doi: 10.1016/j.ahj.2021.04.017. Epub ahead of print.
PMID: 34033802.

Luong P, Glorioso TJ, Grunwald GK, Peterson P, Allen LA, Khanna A, Waughtal J, Sandy L, Ho PM, Bull S. Text Message Medication Adherence Reminders Automated and Delivered at Scale Across Two Institutions: Testing the Nudge System: Pilot Study. Circ Cardiovasc Qual Outcomes. 2021 May 17:CIRCOUTCOMES120007015. doi: 10.1161/CIRCOUTCOMES.120.007015. Epub ahead of print.
PMID: 33993727

Trivedi PS, Jensen AM, Kriss MS, Brown MA, Morgan RL, Lindrooth RC, Ho PM, Ryu RK. Ethnoracial disparity in hospital survival following transjugular intrahepatic portosystemic shunt creation for acute variceal bleeding in the United States. J Vasc Interv Radiol. 2021 Apr 23:S1051-0443(21)01053-8. doi: 10.1016/j.jvir.2021.02.027. Epub ahead of print.
PMID: 33901695

Levy AE, Hammes A, Anoff DL, Raines JD, Beck NM, Rudofker EW, Marshall KJ, Nensel JD, Messenger JC, Masoudi FA, Pierce RG, Allen LA, Ream KS, Ho PM. Acute Myocardial Infarction Cohorts Defined by International Classification of Diseases, Tenth Revision Versus Diagnosis-Related Groups: Analysis of Diagnostic Agreement and Quality Measures in an Integrated Health System. Circ Cardiovasc Qual Outcomes. 2021 Mar 3:CIRCOUTCOMES120006570. doi: 10.1161/CIRCOUTCOMES.120.006570. Epub ahead of print.
PMID: 33653116

Turakhia M, Sundaram V, Smith SN, Ding V, Michael Ho P, Kowey PR, Piccini JP, Foody J, Birmingham MC, Ianus J, Rajmane A, Mahaffey KW; smartADHERE Investigators. Efficacy of a centralized, blended electronic, and human intervention to improve direct oral anticoagulant adherence: Smartphones to improve rivaroxaban ADHEREnce in atrial fibrillation (SmartADHERE) a randomized clinical trial. Am Heart J. 2021 Jul;237:68-78. doi: 10.1016/j.ahj.2021.02.023. Epub 2021 Mar 4.
PMID: 33676886

Fletcher DR, Grunwald GK, Battaglia C, Ho PM, Lindrooth RC, Peterson PN. Association Between Increased Hospital Reimbursement for Cardiac Rehabilitation and Utilization of Cardiac Rehabilitation by Medicare Beneficiaries: An Interrupted Time Series. Circ Cardiovasc Qual Outcomes. 2021 Mar 8:CIRCOUTCOMES120006572. doi: 10.1161/CIRCOUTCOMES.120.006572. Epub ahead of print.
PMID: 33677975

Breathett K, Spatz ES, Kramer DB, Essien UR, Wadhera RK, Peterson PN, Ho PM, Nallamothu BK. The Groundwater of Racial and Ethnic Disparities Research: A Statement From Circulation: Cardiovascular Quality and Outcomes. Circ Cardiovasc Qual Outcomes. 2021 Feb 11:CIRCOUTCOMES121007868. doi: 10.1161/CIRCOUTCOMES.121.007868. Epub ahead of print.
PMID: 33567860

Rentsch CT, Beckman JA, Tomlinson L, Gellad WF, Alcorn C, Kidwai-Khan F, Skanderson M, Brittain E, King JT Jr, Ho YL, Eden S, Kundu S, Lann MF, Greevy RA Jr, Ho PM, Heidenreich PA, Jacobson DA, Douglas IJ, Tate JP, Evans SJW, Atkins D, Justice AC, Freiberg MS. Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study. BMJ. 2021 Feb 11;372:n311. doi: 10.1136/bmj.n311. PMCID: PMC7876672.
PMID: 33574135

McGuinn E, Warsavage T, Plomondon ME, Valle JA, Ho PM, Waldo SW. Association of Ischemic Evaluation and Clinical Outcomes Among Patients Admitted With New-Onset Heart Failure. J Am Heart Assoc. 2021 Feb 15:e019452. doi: 10.1161/JAHA.120.019452. Epub ahead of print.
PMID: 33586468

Marshall V, Stryczek KC, Haverhals L, Young J, Au DH, Ho PM, Kaboli PJ, Kirsh S, Sayre G. The Focus They Deserve: Improving Women Veterans' Health Care Access. Womens Health Issues. 2021 Feb 10:S1049-3867(20)30157-2. doi: 10.1016/j.whi.2020.12.011. Epub ahead of print.
PMID: 33582001

Kini V, Mosley B, Raghavan S, Khazanie P, Bradley SM, Magid DJ, Ho PM, Masoudi FA. Differences in High- and Low-Value Cardiovascular Testing by Health Insurance Provider. J Am Heart Assoc. 2021 Jan 28:e018877. doi: 10.1161/JAHA.120.018877. Epub ahead of print.
PMID: 33506684

Whittington MD, Ho PM, Kirsh SR, Kenney RR, Todd-Stenberg J, Au DH, Simonetti J. Cost savings associated with electronic specialty consultations. Am J Manag Care. 2021 Jan 1;27(1):e16-e23. doi: 10.37765/ajmc.2021.88579.
PMID: 33471464

Lu AD, Gunzburger E, Glorioso TJ, Smith WB 2nd, Kenney RR, Whooley MA, Ho PM. Impact of Longitudinal Virtual Primary Care on Diabetes Quality of Care. J Gen Intern Med. 2021 Jan 22. doi: 10.1007/s11606-020-06547-x. Epub ahead of print. PMCID: PMC7822396.
PMID: 33483815

Bradley SM, Adusumalli S, Amin AP, Borden WB, Das SR, Downey WE, Ebinger JE, Gelbman J, Gluckman TJ, Goyal A, Gupta D, Khot UN, Levy AE, Mutharasan RK, Rush P, Strauss CE, Shreenivas S, Ho PM. The Cardiovascular Quality Improvement and Care Innovation Consortium: Inception of a Multicenter Collaborative to Improve Cardiovascular Care. Circ Cardiovasc Qual Outcomes. 2021 Jan 12:CIRCOUTCOMES120006753. doi: 10.1161/CIRCOUTCOMES.120.006753. Epub ahead of print.
PMID: 33430610

2020

Althoff MD, Holguin F, Yang F, Grunwald GK, Moss M, Vandivier RW, Ho PM, Kiser TH, Burnham EL. Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations. Am J Respir Crit Care Med. 2020 Dec 1;202(11):1520-1530. doi: 10.1164/rccm.201910-2021OC. PMCID: PMC7706169.
PMID: 32663410

Dhaliwal JS, Goss F, Whittington MD, Bookman K, Ho PM, Zane R, Wiler J. Reduced admission rates and resource utilization for chest pain patients using an electronic health record-embedded clinical pathway in the emergency department. J Am Coll Emerg Physicians Open. 2020 Nov 17;1(6):1602-1613. doi: 10.1002/emp2.12308. PMCID: PMC7771814.
PMID: 33392569

Rentsch CT, Beckman JA, Tomlinson L, Gellad WF, Alcorn C, Kidwai-Khan F, Skanderson M, Brittain E, King JT, Ho YL, Eden S, Kundu S, Lann MF, Greevy RA, Ho PM, Heidenreich PA, Jacobson DA, Douglas IJ, Tate JP, Evans SJ, Atkins D, Justice AC, Freiberg MS. Early initiation of prophylactic anticoagulation for prevention of COVID-19 mortality: a nationwide cohort study of hospitalized patients in the United States. medRxiv [Preprint]. 2020 Dec 11:2020.12.09.20246579. doi: 10.1101/2020.12.09.20246579. PMCID: PMC7743107.
PMID: 33330896

Kini V, Hess PL, Liu W, Grunwald G, Ho PM, Bradley SM. Association Between Elective Percutaneous Coronary Intervention Appropriateness and Publicly Reported Outcomes. Circ Cardiovasc Qual Outcomes. 2020 Nov 9. doi: 10.1161/CIRCOUTCOMES.120.007421. Epub ahead of print.
PMID: 33161758

Leppert MH, Ho PM, Burke J, Madsen TE, Kleindorfer D, Sillau S, Daugherty S, Bradley CJ, Poisson SN. Young Women Had More Strokes Than Young Men in a Large, United States Claims Sample. Stroke. 2020 Nov;51(11):3352-3355. doi: 10.1161/STROKEAHA.120.030803. Epub 2020 Sep 18.
PMID: 32942966

Salahuddin T, Richardson V, McNeal DM, Henderson K, Hess PL, Raghavan S, Saxon DR, Valle JA, Waldo SW, Ho PM, Schwartz GG. Potential unrealized mortality benefit of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transport-2 inhibitors: A report from the Veterans Health Administration Clinical Assessment, Reporting and Tracking program. Diabetes Obes Metab. 2021 Jan;23(1):97-105. doi: 10.1111/dom.14193. Epub 2020 Oct 3.
PMID: 32902128

Waldo SW, Glorioso TJ, Barón AE, Plomondon ME, Valle JA, Schofield R, Ho PM. Outcomes Among Patients Undergoing Elective Percutaneous Coronary Intervention at Veterans Affairs and Community Care Hospitals. J Am Coll Cardiol. 2020 Sep 1;76(9):1112-1116. doi: 10.1016/j.jacc.2020.05.086.PMID:
PMID: 32854846

Raghavan S, Liu WG, Berkowitz SA, Barón AE, Plomondon ME, Maddox TM, Reusch JEB, Ho PM, Caplan L. Association of Glycemic Control Trajectory with Short-Term Mortality in Diabetes Patients with High Cardiovascular Risk: a Joint Latent Class Modeling Study. J Gen Intern Med. 2020 Aug;35(8):2266-2273. doi: 10.1007/s11606-020-05848-5. Epub 2020 Apr 24. PMCID: PMC7403288.
PMID: 32333313

Simon S, Ho PM. Ethnic and Racial Disparities in Acute Myocardial Infarction. Curr Cardiol Rep. 2020 Jul 9;22(9):88. doi: 10.1007/s11886-020-01351-9.
PMID: 32648143

Grunwald GK, Arnett JA, Liu W, Ho PM. Bayesian profiling for cost with zeros to decompose total cost into probability of cost and mean nonzero cost. Biom J. 2020 Nov;62(7):1631-1649. doi: 10.1002/bimj.201900148. Epub 2020 Jun 15.
PMID: 32542678

Ball S, Stryczek K, Stevenson L, Hearns R, Au DH, Ho PM, Aron DC. A Qualitative Evaluation of the Pain Management VA-ECHO Program Using the RE-AIM Framework: The Participant's Perspective. Front Public Health. 2020 May 15;8:169. doi: 10.3389/fpubh.2020.00169. eCollection 2020.
PMID: 32500053

Ho PM. Value in Healthcare Special Issue. Circ Cardiovasc Qual Outcomes. 2020 May;13(5):e006817. doi: 10.1161/CIRCOUTCOMES.120.006817. Epub 2020 May 12.
PMID: 32393126

Hess PL, Kini V, Liu W, Roldan P, Autruong P, Grunwald GK, O'Donnell C, Doll JA, Ho PM, Bradley SM. Appropriateness of Percutaneous Coronary Interventions in Patients With Stable Coronary Artery Disease in US Department of Veterans Affairs Hospitals From 2013 to 2015. JAMA Netw Open. 2020 Apr 1;3(4):e203144. doi: 10.1001/jamanetworkopen.2020.3144.
PMID: 32315067

Asundi A, Stanislawski M, Mehta P, Mull HJ, Schweizer ML, Barón AE, Ho PM, Gupta K, Branch-Elliman W. Development and Validation of a Semi-Automated Surveillance Algorithm for Cardiac Device Infections: Insights from the VA CART program. Sci Rep. 2020 Mar 24;10(1):5276. doi: 10.1038/s41598-020-62083-y.
PMID: 32210289

Neugebauer R, Schroeder EB, Reynolds K, Schmittdiel JA, Loes L, Dyer W, Desai JR, Vazquez-Benitez G, Ho PM, Anderson JP, Pimentel N, O'Connor PJ. Comparison of Mortality and Major Cardiovascular Events Among Adults With Type 2 Diabetes Using Human vs Analogue Insulins. JAMA Netw Open. 2020 Jan 3;3(1):e1918554. doi: 10.1001/jamanetworkopen.2019.18554.
PMID: 31977057

Hess PL, Sheng S, Matsouaka R, DeVore AD, Heidenreich PA, Yancy CW, Bhatt DL, Allen LA, Peterson PN, Ho PM, Lewis WR, Hernandez AF, Fonarow GC, Piccini JP. Strict Versus Lenient Versus Poor Rate Control Among Patients With Atrial Fibrillation and Heart Failure (from the Get With The Guidelines - Heart Failure Program). Am J Cardiol. 2020 Mar 15;125(6):894-900. doi: 10.1016/j.amjcard.2019.12.025. Epub 2019 Dec 30.
PMID: 31980141

Maw AM, Thompson LE, Ho PM, Kennedy KF, Maddox TM, Valle JA, Sandhu A, Masoudi FA, Messerli FH, Daugherty SL. Implications of Guideline Updates for the Management of Apparent Treatment Resistant Hypertension in the United States (A NCDR Research to Practice [R2P] Project). Am J Cardiol. 2020 Jan 1;125(1):63-67. doi: 10.1016/j.amjcard.2019.09.033. Epub 2019 Oct 11. PMCID: PMC7232963.
PMID: 31727262

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Special Projects

Veteran Access Research Consortium (VARC)

The overall goal is to leverage the learning healthcare system (LHS) framework to accelerate access-related health systems research and build a community of researchers with the goal of improving access to care for Veterans. The CORE will create four cross-cutting workgroups: 1) portfolio review; 2) metrics; 3) research community; and 4) stakeholder engagement. The workgroups will align to develop an access research roadmap and identify high priority access research questions for potential funding by HSR and/or operational partners.

Learn more

VA Collaborative Evaluation Center (VACE)

A highly collaborative VA “virtual center” composed of quantitative, qualitative, and mixed methods evaluation experts.

Evaluate implementation of VA initiatives to assess effectiveness and barriers and facilitators to implementation, as well as unintended consequences.

Work collaboratively with operational partners to ensure evaluation outcomes are relevant and useful for program improvements and sustainability.

Learn more: https://www.seattledenvercoin.research.va.gov/Research/vace/

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Media (Webinars, Podcast, Other)

COnsortia of REsearch:
Access Research Priorities: Perspectives of the Office of Veterans Access to Care (OVAC) and Veterans Access Research Consortium

by Michael Ho, MD, PhD ; Susan Kirsh, MD, MPH
Seminar date: 9/22/2020

Description: Drs. Kirsh and Ho will make presentations to address the following items: i. Describe the access core and its goals ii. Summarize the recommendations from the recent National Academies of Sciences, Engineering, Medicine workshop on developing a patient-centered approach to optimizing Veterans’ access to health care services iii. OVAC priority areas for access

Watch: https://www.hsrd.research.va.gov/for_researchers/cyber_seminars/archives/video_archive.cfm?SessionID=3850

Patient Aligned Care Teams (PACT) Demonstration Labs:
Introduction to the HSR Veterans Access Research Consortium (VARC)

by Michael Ho, MD, PhD ; Peter Kaboli, MD, MS, FACP, FHM ; Sameer Saini, MD ; Stephanie Shimada, PhD
Seminar date: 2/19/2020

Description: This Cyberseminar will introduce the audience to the Consortium’s purpose, structure, and proposed milestones. Each VARC workgroup will describe their planned work. VARC members will also introduce an upcoming survey to be administered to VA access researchers as well as present a plan for communication, consultation, and collaboration between access researchers, the VARC, and operational partners. Intended Audience: Researchers and operational partners interested in Veterans' access to care.

Watch: https://www.hsrd.research.va.gov/for_researchers/cyber_seminars/archives/video_archive.cfm?SessionID=3766

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