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Seattle-Denver Center of Innovation (COIN)


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COIN Investigators & Staff

COIN Investigators


Christian D. Helfrich, PhD, MPH
Title: Research Assistant Professor, Department of Health Services at the University of Washington School of Public Health
Location: Seattle
University of Washington webpage
See Dr. Helfrich's Dimensions profile that includes: publications, grants, datasets, patents and clinical trials
Dr. Helfrich is a Core Investigator with HSR&D, Research Assistant Professor, Department of Health Services at the University of Washington School of Public Health, and Implementation Research Coordinator for the VA Ischemic Heart Disease Quality Enhancement Research Initiative, a collaboration between VA Health Services Research and Clinical Operations to speed the adoption and implementation of evidence-based practices for priority conditions among Veterans. Dr. Helfrich is also Chair of the Organizational Function Working Group, a part of the VA Patient Aligned Care Team (PACT). Demonstration Laboratory Coordinating Center, which is tasked with evaluating the implementation of a patient-centered medical home model in VA. His primary research interests are organizational change and implementation science, specifically on assessing organizational readiness to change in the context of evidence-based practices, and factors influencing implementation of large scale initiatives. Dr. Helfrich received his PhD in Health Policy and Management from the University of North Carolina at Chapel Hill, and his MPH from the Department of Health Services at the University of Washington School of Public Health.

The following images visualize Dr. Helfrich's work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):

Dr. Helfrich's publication titles indicate his primary work is care of Veterans
Word cloud from pub titles
Dr. Helfrich's collaborations are primarily from the University of Washington
Research collaboration map
The following research fields have been used to summarize Dr. Helfrich's publications and grants. The categories are based on 92 publications and 4 grants.
Publications Grants
Clinical Research Health Services
Health Services Clinical Research
Prevention Clinical Trials and Supportive Activities
Behavioral and Social Science Chronic Obstructive Pulmonary Disease
Cardiovascular Mental Health
Heart Disease Lung
Heart Disease - Coronary Heart Disease Behavioral and Social Science
Clinical Trials and Supportive Activities Infectious Diseases
Patient Safety Rare Diseases

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Recent Publications



O'Connor AW, Wong ES, Nelson KM, Sears JM, Helfrich CD. Patient Enrollment Growth and Burnout in Primary Care at the Veterans Health Administration. J Gen Intern Med. 2023 Jan 25. doi: 10.1007/s11606-023-08034-5. Epub ahead of print. PMID: 36697928
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O'Connor AW, Helfrich CD, Nelson KM, Sears JM, Singh H, Wong ES. Changes in electronic notification volume and primary care provider burnout. Am J Manag Care. 2023 Jan;29(1):57-63. doi: 10.37765/ajmc.2023.89304. PMID: 36716155
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Sanchez A, Elizondo-Alzola U, Pijoan JI, Mediavilla MM, Pablo S, Sainz de Rozas R, Lekue I, Gonzalez-Larragan S, Llarena M, Larrañaga O, Helfrich CD, Grandes G. Applying the behavior change wheel to design de-implementation strategies to reduce low-value statin prescription in primary prevention of cardiovascular disease in primary care. Front Med (Lausanne). 2022 Oct 13;9:967887. doi: 10.3389/fmed.2022.967887. PMCID: PMC9606599. PMID: 36314033
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Edelman EJ, Gan G, Dziura J, Esserman D, Porter E, Becker WC, Chan PA, Cornman DH, Helfrich CD, Reynolds J, Yager JE, Morford KL, Muvvala SB, Fiellin DA. Effect of Implementation Facilitation to Promote Adoption of Medications for Addiction Treatment in US HIV Clinics: A Randomized Clinical Trial. JAMA Netw Open. 2022 Oct 3;5(10):e2236904. doi: 10.1001/jamanetworkopen.2022.36904. PMID: 36251291
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Fishleder S, Harris JR, Petrescu-Prahova M, Kohn M, Helfrich CD. Development and Feasibility Testing of the Clinical-Community Linkage Self-Assessment Survey for Community Organizations. Front Public Health. 2022 May 20;10:797468. doi: 10.3389/fpubh.2022.797468. PMCID: PMC9163549. PMID: 35669755
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Doll JA, Beaver K, Naranjo D, Waldo SW, Maynard C, Helfrich CD, Rao SV. Trends in Arterial Access Site Selection and Bleeding Outcomes Following Coronary Procedures, 2011-2018. Circ Cardiovasc Qual Outcomes. 2022 Mar 11:CIRCOUTCOMES121008359. doi: 10.1161/CIRCOUTCOMES.121.008359. Epub ahead of print. PMID: 35272504
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Harris JR, Kava CM, Chan KCG, Kohn MJ, Hammerback K, Parrish AT, Helfrich CD, Hannon PA. Pathways to Employee Outcomes in a Workplace Health Promotion Program. Am J Health Promot. 2022 Jan 4:8901171211066898. doi: 10.1177/08901171211066898. Epub ahead of print. PMID: 34983199
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Duan KI, Helfrich CD, Rao SV, Neely EL, Sulc CA, Naranjo D, Wong ES. Cost analysis of a coaching intervention to increase use of transradial percutaneous coronary intervention. Implement Sci Commun. 2021 Oct 27;2(1):123. doi: 10.1186/s43058-021-00219-5. PMCID: PMC8554885. PMID: 34706775.

Beaver K, Naranjo D, Doll J, Maynard C, Taylor L, Plomondon M, Waldo S, Helfrich CD, Rao SV. Design and baseline results of a coaching intervention for implementation of trans-radial access in percutaneous coronary intervention. Contemp Clin Trials. 2021 Oct 25:106606. doi: 10.1016/j.cct.2021.106606. Epub ahead of print. PMID: 34710590

Schuttner L, Haraldsson B, Maynard C, Helfrich CD, Reddy A, Parikh T, Nelson KM, Wong E. Factors Associated With Low-Value Cancer Screenings in the Veterans Health Administration. JAMA Netw Open. 2021 Oct 1;4(10):e2130581. doi: 10.1001/jamanetworkopen.2021.30581. PMID: 34677595.

Sterling R, Rinne ST, Reddy A, Moldestad M, Kaboli P, Helfrich CD, Henrikson NB, Nelson KM, Kaminetzky C, Wong ES. Identifying and Prioritizing Workplace Climate Predictors of Burnout Among VHA Primary Care Physicians. J Gen Intern Med. 2021 Jul 29:1–8. doi: 10.1007/s11606-021-07006-x. Epub ahead of print. PMCID: PMC8321506. PMID: 34327656

Damschroder LJ, Knighton AJ, Griese E, Greene SM, Lozano P, Kilbourne AM, Buist DSM, Crotty K, Elwy AR, Fleisher LA, Gonzales R, Huebschmann AG, Limper HM, Ramalingam NS, Wilemon K, Ho PM, Helfrichfcr CD. Recommendations for strengthening the role of embedded researchers to accelerate implementation in health systems: Findings from a state-of-the-art (SOTA) conference workgroup. Healthc (Amst). 2021 Jun;8 Suppl 1:100455. doi: 10.1016/j.hjdsi.2020.100455. PMID: 34175093.

Ailabouni NJ, Reeve E, Helfrich CD, Hilmer SN, Wagenaar BH. Leveraging implementation science to increase the translation of deprescribing evidence into practice. Res Social Adm Pharm. 2021 Jun 6:S1551-7411(21)00184-4. doi: 10.1016/j.sapharm.2021.05.018. Epub ahead of print. PMID: 34147372

Kononowech J, Hagedorn H, Hall C, Helfrich CD, Lambert-Kerzner AC, Miller SC, Sales AE, Damschroder L. Mapping the organizational readiness to change assessment to the Consolidated Framework for Implementation Research. Implement Sci Commun. 2021 Feb 13;2(1):19. doi: 10.1186/s43058-021-00121-0. PMID: 33581728



Helfrich CD, Savitz LA. Responding to the Call: a New JGIM Area of Emphasis for Implementation and Quality Improvement Sciences. J Gen Intern Med. 2020 Nov;35(Suppl 2):781-782. doi: 10.1007/s11606-020-06229-8. PMCID: PMC7587537. PMID: 33106999

Parikh TJ, Stryczek KC, Gillespie C, Sayre GG, Feemster L, Udris E, Majerczyk B, Rinne ST, Wiener RS, Au DH, Helfrich CD. Provider anticipation and experience of patient reaction when deprescribing guideline discordant inhaled corticosteroids. PLoS One. 2020 Sep 17;15(9):e0238511. doi: 10.1371/journal.pone.0238511. PMCID: PMC7498097. PMID: 32941462

Simonetti JA, Clinton WL, Taylor L, Mori A, Fihn SD, Helfrich CD, Nelson K. The impact of survey nonresponse on estimates of healthcare employee burnout. Healthc (Amst). 2020 Sep;8(3):100451. doi: 10.1016/j.hjdsi.2020.100451. Epub 2020 Aug 2. PMID: 32919589

Goebel MC, Trautner BW, Wang Y, Van JN, Dillon LM, Patel PK, Drekonja DM, Graber CJ, Shukla BS, Lichtenberger P, Helfrich CD, Sales A, Grigoryan L. Organizational readiness assessment in acute and long-term care has important implications for antibiotic stewardship for asymptomatic bacteriuria. Am J Infect Control. 2020 Nov;48(11):1322-1328. doi: 10.1016/j.ajic.2020.04.024. Epub 2020 May 8. PMCID: PMC7606359. PMID: 32437753

Winchester DE, Merritt J, Waheed N, Norton H, Manja V, Shah NR, Helfrich CD. Implementation of Appropriate Use Criteria for Cardiology Tests and Procedures: a Systematic Review and Meta-analysis. Eur Heart J Qual Care Clin Outcomes. 2020 Mar 31:qcaa029. doi: 10.1093/ehjqcco/qcaa029. Epub ahead of print. PMID: 32232436

Gamble-George JC, Longenecker CT, Webel AR, Au DH, Brown AF, Bosworth H, Crothers K, Cunningham WE, Fiscella KA, Hamilton AB, Helfrich CD, Ladapo JA, Luque A, Tobin JN, Wyatt GE; Implementation Research to Develop Interventions for People Living with HIV (PRECluDE) Consortium. ImPlementation REsearCh to DEvelop Interventions for People Living with HIV (the PRECluDE consortium): Combatting chronic disease comorbidities in HIV populations through implementation research. Prog Cardiovasc Dis. 2020 Mar-Apr;63(2):79-91. doi: 10.1016/j.pcad.2020.03.006. Epub 2020 Mar 19. PMCID: PMC7237329. PMID: 32199901

Brown MC, Harris JR, Hammerback K, Kohn MJ, Parrish AT, Chan GK, Ornelas IJ, Helfrich CD, Hannon PA. Development of a Wellness Committee Implementation Index for Workplace Health Promotion Programs in Small Businesses. Am J Health Promot. 2020 Jul;34(6):614-621. doi: 10.1177/0890117120906967. Epub 2020 Feb 20. PMCID: PMC7305966. PMID: 32077300

Sanchez A, Pijoan JI, Pablo S, Mediavilla M, de Rozas RS, Lekue I, Gonzalez-Larragan S, Lantaron G, Argote J, García-Álvarez A, Latorre PM, Helfrich CD, Grandes G. Addressing low-value pharmacological prescribing in primary prevention of CVD through a structured evidence-based and theory-informed process for the design and testing of de-implementation strategies: the DE-imFAR study. Implement Sci. 2020 Jan 22;15(1):8. doi: 10.1186/s13012-020-0966-3. PMCID: PMC6977270. PMID: 31969175



Rymer JA, O'Donnell CI, Plomondon ME, Hess PL, Donahue M, Hebert PL, Shroff A, Swaminathan RV, Waldo SW, Seto AH, Helfrich CD, Rao SV. Same-day discharge among patients undergoing elective PCI: Insights from the VA CART Program. Am Heart J. 2019 Dec;218:75-83. doi: 10.1016/j.ahj.2019.09.003. Epub 2019 Sep 12. PMID: 31707331

Stryczek K, Lea C, Gillespie C, Sayre G, Wanner S, Rinne ST, Wiener RS, Feemster L, Udris E, Au DH, Helfrich CD. De-implementing Inhaled Corticosteroids to Improve Care and Safety in COPD Treatment: Primary Care Providers' Perspectives. J Gen Intern Med. 2020 Jan;35(1):51-56. doi: 10.1007/s11606-019-05193-2. Epub 2019 Aug 8. PMCID: PMC6957635. PMID: 31396814

Parikh TJ, Helfrich CD, Quiñones AR, Marshall-Fabien GL, Makaroun LK, Black MA, Thielke SM. Cost-related delay in filling prescriptions and health care ratings among medicare advantage recipients. Medicine (Baltimore). 2019 Aug;98(31):e16469. doi: 10.1097/MD.0000000000016469. PMC6708951 PMID: 31374008

Helfrich CD, Hartmann CW, Parikh TJ, Au DH. Promoting Health Equity through De-Implementation Research. Ethn Dis. 2019 Feb 21;29(Suppl 1):93-96. doi: 10.18865/ed.29.S1.93. eCollection 2019. PMC6428172 PMID: 30906155

Whittington MD, Ho PM, Helfrich CD. Recommendations for the Use of Audit and Feedback to De-Implement Low-Value Care. Am J Med Qual. 2019 Jul/Aug;34(4):409-411. doi: 10.1177/1062860618824153. Epub 2019 Jan 17. PMID: 30654620

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Grants & Funding


AdvanCing High quality COPD care for people with immune dysfunction by implementing Evidence-based management through proactive E-consults (ACHIEVE)

NIH website: